Microfabricated device measures cellular forces during tissue development (w/Video)
نویسنده
چکیده
Immunofluorescence sections of cells embedded within a micropatterned collagen gel. Cells generate forces within a tissue that can feedback to regulate the accumulation of cytoskeletal proteins such as actin (green) and structural matrix proteins such as fibronectin or tenascin C (red). These forces can be measured using elastomeric cantilevers (white) that deflect in response to tissue forces. Cell nuclei are labeled in blue. Credit: Image courtesy of Wesley R. Legant
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